Two sample MR report
MGP_Endothelial Cell (Endo) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.0086366 | 0.1601041 | 0.9595667 |
| Weighted median | 6 | 0.0234678 | 0.0111858 | 0.0359053 |
| Inverse variance weighted | 6 | 0.0228622 | 0.0094191 | 0.0152149 |
| Simple mode | 6 | 0.0246649 | 0.0154791 | 0.1719436 |
| Weighted mode | 6 | 0.0245342 | 0.0149569 | 0.1618621 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0453782 | 4 | 0.9997465 |
| Inverse variance weighted | 0.0533003 | 5 | 0.9999658 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0074869 | 0.0841164 | 0.9333551 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 8.9e-05 | 0 | TRUE | 0.3698304 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
